Product Data Sheet
STAT3-IN-20
Catalog No. A36522
STAT3-IN-20 is a selective inhibitor of the STAT3 protein, exhibiting an IC50 value of 0.65 μM. By binding to the SH2 domain, this compound effectively inhibits STAT3 phosphorylation, translocation, and subsequent downstream gene transcription. Demonstrating significant antiproliferative activity, STAT3-IN-20 shows IC50 values of 2.97 μM against STAT3-overactivated DU145 cells and 3.26 μM against MDA-MB-231 cancer cells. Furthermore, STAT3-IN-20 induces cell cycle arrest and apoptosis, making it a valuable tool for research in cancer therapeutics targeting the STAT3 signaling pathway.
Chemical Information
| Catalog Num | A36522 |
|---|---|
| M. Wt | 593.64 |
| Formula | C30H27F4N7S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2768427-54-7 |
| Synonyms | |
| SMILES | FC1=CC=C(C2=NC3=CC(NC4=NN=C(S4)C5=CC=C(C=C5)C(F)(F)F)=C(C=C3N2C6CC6)N7CCN(CC7)C)C=C1 |
Biological Activity
| Description | STAT3-IN-20 is a selective inhibitor of the STAT3 protein, exhibiting an IC50 value of 0.65 μM. By binding to the SH2 domain, this compound effectively inhibits STAT3 phosphorylation, translocation, and subsequent downstream gene transcription. Demonstrating significant antiproliferative activity, STAT3-IN-20 shows IC50 values of 2.97 μM against STAT3-overactivated DU145 cells and 3.26 μM against MDA-MB-231 cancer cells. Furthermore, STAT3-IN-20 induces cell cycle arrest and apoptosis, making it a valuable tool for research in cancer therapeutics targeting the STAT3 signaling pathway. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
