Product Data Sheet
Cycloguanil-d6 (hydrochloride)
Catalog No. A36563
Cycloguanil-d6 (hydrochloride) is a deuterium-labeled derivative of Cycloguanil, a potent inhibitor of dihydrofolate reductase (DHFR). With an IC50 of 10.8 μM against human DHFR, this stable isotope disrupts the folate metabolic pathway, leading to impaired nucleotide synthesis and DNA replication. Cycloguanil-d6 (hydrochloride) is utilized in malaria research due to its efficacy against Plasmodium DHFR, and it demonstrates significant potential in cancer research by inhibiting DHFR in human cancer cells and blocking STAT3 transcriptional activity.
Chemical Information
| Catalog Num | A36563 |
|---|---|
| M. Wt | 294.21 |
| Formula | C11H9D6Cl2N5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2712364-69-5 |
| Synonyms | Chlorguanide triazine-d6 (hydrochloride) |
| SMILES | [2H]C([2H])([2H])C1(N(C2=CC=C(C=C2)Cl)C(N)=NC(N)=N1)C([2H])([2H])[2H].Cl |
Biological Activity
| Description | Cycloguanil-d6 (hydrochloride) is a deuterium-labeled derivative of Cycloguanil, a potent inhibitor of dihydrofolate reductase (DHFR). With an IC50 of 10.8 μM against human DHFR, this stable isotope disrupts the folate metabolic pathway, leading to impaired nucleotide synthesis and DNA replication. Cycloguanil-d6 (hydrochloride) is utilized in malaria research due to its efficacy against Plasmodium DHFR, and it demonstrates significant potential in cancer research by inhibiting DHFR in human cancer cells and blocking STAT3 transcriptional activity. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
