Product Data Sheet
IK-595
Catalog No. A36684
IK-595 is a selective inhibitor of MEK1 and MEK2, exhibiting a high binding affinity of 7.39 nM. It effectively blocks EGF-induced phosphorylation of ERK1/2 in AsPC-1 cells, with an IC50 of 0.1 nM. Notably, IK-595 demonstrates oral bioavailability and the ability to penetrate the blood-brain barrier, making it a valuable tool for investigating Ras/MAPK pathway-altered cancers.
Chemical Information
| Catalog Num | A36684 |
|---|---|
| M. Wt | 675.90 |
| Formula | C24H24ClFIN5O5S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3018909-73-1 |
| Synonyms | |
| SMILES | CNS(=O)(NC1=C(C(OC2=C(C(N(C(NC3=C(C=C(I)C=C3)F)=C2C(NC4CC4)=O)C)=O)C)=CC=C1)Cl)=O |
Biological Activity
| Description | IK-595 is a selective inhibitor of MEK1 and MEK2, exhibiting a high binding affinity of 7.39 nM. It effectively blocks EGF-induced phosphorylation of ERK1/2 in AsPC-1 cells, with an IC50 of 0.1 nM. Notably, IK-595 demonstrates oral bioavailability and the ability to penetrate the blood-brain barrier, making it a valuable tool for investigating Ras/MAPK pathway-altered cancers. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
