Product Data Sheet
PROTAC MEK1 Degrader-1
Catalog No. A36687
PROTAC MEK1 Degrader-1 is a targeted protein degradation compound that selectively degrades MEK1 via a PROTAC mechanism. With a pIC50 value of 7.0, it effectively inhibits ERK1/2 phosphorylation, leading to downstream signaling modulation. This compound demonstrates significant antiproliferative activity against A375 melanoma cells, making it a valuable tool for research in cancer therapeutics and signaling pathway studies.
Chemical Information
| Catalog Num | A36687 |
|---|---|
| M. Wt | 1201.17 |
| Formula | C53H66FIN8O11S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2671004-41-2 |
| Synonyms | |
| SMILES | O=S(NC(C=C(C(N1C)=O)C)=C1NC2=C(C=C(C=C2)I)F)(C3=CC=C(C=C3)CCC(NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@H](C4)O)C(N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C)=O)=O)=O)=O)=O |
Biological Activity
| Description | PROTAC MEK1 Degrader-1 is a targeted protein degradation compound that selectively degrades MEK1 via a PROTAC mechanism. With a pIC50 value of 7.0, it effectively inhibits ERK1/2 phosphorylation, leading to downstream signaling modulation. This compound demonstrates significant antiproliferative activity against A375 melanoma cells, making it a valuable tool for research in cancer therapeutics and signaling pathway studies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
