Product Data Sheet
SKI2496
Catalog No. A36781
SKI2496 is a potent GnRH receptor antagonist that exhibits an IC50 of 0.25 nM for human GnRHR, demonstrating high specificity across species with values of 13.2 nM for monkey and 279.2 nM for rat receptors. This compound effectively inhibits Ca2+ influx with an IC50 of 0.76 nM and blocks ERK1/2 phosphorylation with an IC50 of 2.6 nM. SKI2496 is utilized in research focused on sex hormone-dependent disorders, particularly for its ability to reduce serum LH concentrations.
Chemical Information
| Catalog Num | A36781 |
|---|---|
| M. Wt | 739.68 |
| Formula | C35H36F7N5O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1308378-95-1 |
| Synonyms | |
| SMILES | O=C(O)CCCN[C@H](C1=CC=CC=C1)CN(C(N(CC2=C(C(F)(F)F)C=CC=C2F)C(C)=C3N4CCN(CC5=CC=C(C(F)(F)F)O5)CC4)=O)C3=O |
Biological Activity
| Description | SKI2496 is a potent GnRH receptor antagonist that exhibits an IC50 of 0.25 nM for human GnRHR, demonstrating high specificity across species with values of 13.2 nM for monkey and 279.2 nM for rat receptors. This compound effectively inhibits Ca2+ influx with an IC50 of 0.76 nM and blocks ERK1/2 phosphorylation with an IC50 of 2.6 nM. SKI2496 is utilized in research focused on sex hormone-dependent disorders, particularly for its ability to reduce serum LH concentrations. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
