Product Data Sheet
NRL-1049 dihydrochloride
Catalog No. A36792
NRL-1049 dihydrochloride is a selective inhibitor of rho-associated protein kinase 2 (ROCK2), exhibiting an IC50 value of 0.59 μM. This compound demonstrates a remarkable selectivity for ROCK2 over ROCK1, with an IC50 of 26 μM, effectively inhibiting ROCK2 activity. NRL-1049 dihydrochloride has significant potential in research applications focused on the preservation of the blood-brain barrier following acute injury.
Chemical Information
| Catalog Num | A36792 |
|---|---|
| M. Wt | 392.34 |
| Formula | C16H23Cl2N3O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1973494-17-5 |
| Synonyms | BA-1049 |
| SMILES | C[C@H](C1CCN(CC1)S(=O)(C2=C3C=CN=CC3=CC=C2)=O)N.Cl.Cl |
Biological Activity
| Description | NRL-1049 dihydrochloride is a selective inhibitor of rho-associated protein kinase 2 (ROCK2), exhibiting an IC50 value of 0.59 μM. This compound demonstrates a remarkable selectivity for ROCK2 over ROCK1, with an IC50 of 26 μM, effectively inhibiting ROCK2 activity. NRL-1049 dihydrochloride has significant potential in research applications focused on the preservation of the blood-brain barrier following acute injury. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
