Product Data Sheet
CAY10746
Catalog No. A36805
CAY10746 is a selective inhibitor of Rho-associated protein kinase (ROCK), demonstrating potent inhibitory activity against ROCK I and ROCK II with IC50 values of 0.014 μM and 0.003 μM, respectively. This compound is particularly relevant for research into diabetic retinopathy (DR) and other conditions associated with abnormal vascular function. Its ability to modulate ROCK activity makes it a valuable tool in studying cellular pathways involved in inflammation and tissue remodeling.
Chemical Information
| Catalog Num | A36805 |
|---|---|
| M. Wt | 457.48 |
| Formula | C26H23N3O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2247240-76-0 |
| Synonyms | |
| SMILES | O=C1C=COC2=CC(OCC(NC3=CC(NC(C4=CC=C(N(C)C)C=C4)=O)=CC=C3)=O)=CC=C12 |
Biological Activity
| Description | CAY10746 is a selective inhibitor of Rho-associated protein kinase (ROCK), demonstrating potent inhibitory activity against ROCK I and ROCK II with IC50 values of 0.014 μM and 0.003 μM, respectively. This compound is particularly relevant for research into diabetic retinopathy (DR) and other conditions associated with abnormal vascular function. Its ability to modulate ROCK activity makes it a valuable tool in studying cellular pathways involved in inflammation and tissue remodeling. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
