Product Data Sheet
Fasudil hydrochloride semihydrate
Catalog No. A36822
Fasudil hydrochloride semihydrate is a nonspecific inhibitor of RhoA and Rho-associated protein kinase (ROCK), exhibiting a Ki value of 0.33 μM for ROCK1. It shows inhibitory effects on various protein kinases, demonstrating IC50 values of 0.158 μM for ROCK2, and higher values for PKA, PKC, and PKG. Additionally, Fasudil acts as a potent antagonist of calcium channels and displays vasodilatory properties, making it relevant in studies of cardiovascular function and cellular signaling pathways.
Chemical Information
| Catalog Num | A36822 |
|---|---|
| M. Wt | 673.68 |
| Formula | C14H19ClN3O2.5S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 186694-02-0 |
| Synonyms | HA-1077 hydrochloride semihydrate; AT877 hydrochloride semihydrate |
| SMILES | O=S(C1=CC=CC2=C1C=CN=C2)(N3CCNCCC3)=O.[H]Cl.[0.5H2O] |
Biological Activity
| Description | Fasudil hydrochloride semihydrate is a nonspecific inhibitor of RhoA and Rho-associated protein kinase (ROCK), exhibiting a Ki value of 0.33 μM for ROCK1. It shows inhibitory effects on various protein kinases, demonstrating IC50 values of 0.158 μM for ROCK2, and higher values for PKA, PKC, and PKG. Additionally, Fasudil acts as a potent antagonist of calcium channels and displays vasodilatory properties, making it relevant in studies of cardiovascular function and cellular signaling pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
