Product Data Sheet
ROCK-IN-9
Catalog No. A36835
ROCK-IN-9 is a selective inhibitor of Rho-associated protein kinase (ROCK). This compound exhibits cytotoxic effects in HepG2 cells with an IC50 value of 40.8 μM. Additionally, ROCK-IN-9 demonstrates favorable pharmacokinetic properties in murine models, indicating significant in vivo exposure and oral bioavailability at lower doses. Its profile makes it a valuable reagent for research focused on cancer biology and signaling pathways associated with ROCK inhibition.
Chemical Information
| Catalog Num | A36835 |
|---|---|
| M. Wt | 381.40 |
| Formula | C20H20FN5O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2643334-76-1 |
| Synonyms | |
| SMILES | O=C(N1C2=C(CC1)C=C(C3=CNN=C3N)C(F)=C2)NCC4=CC(OC)=CC=C4 |
Biological Activity
| Description | ROCK-IN-9 is a selective inhibitor of Rho-associated protein kinase (ROCK). This compound exhibits cytotoxic effects in HepG2 cells with an IC50 value of 40.8 μM. Additionally, ROCK-IN-9 demonstrates favorable pharmacokinetic properties in murine models, indicating significant in vivo exposure and oral bioavailability at lower doses. Its profile makes it a valuable reagent for research focused on cancer biology and signaling pathways associated with ROCK inhibition. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
