Product Data Sheet
ROCK-IN-10
Catalog No. A36836
ROCK-IN-10 is a highly selective inhibitor of Rho-associated protein kinases (ROCK1 and ROCK2), exhibiting IC50 values of 6 nM and 4 nM, respectively. This compound demonstrates over 100-fold selectivity for ROCK over other kinases, making it an invaluable tool for research applications related to cellular signaling, cytoskeletal dynamics, and the study of various pathological conditions, including cancer and cardiovascular diseases. Researchers can utilize ROCK-IN-10 to investigate the role of ROCK in cellular processes and to explore potential therapeutic strategies targeting these kinases.
Chemical Information
| Catalog Num | A36836 |
|---|---|
| M. Wt | 443.50 |
| Formula | C25H25N5O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1038549-25-5 |
| Synonyms | |
| SMILES | O=C(C1=CC=C(NC(NCC2=CC(C(NC3=CC=C4C(CNCC4)=C3)=O)=CC=C2)=O)C=C1)N |
Biological Activity
| Description | ROCK-IN-10 is a highly selective inhibitor of Rho-associated protein kinases (ROCK1 and ROCK2), exhibiting IC50 values of 6 nM and 4 nM, respectively. This compound demonstrates over 100-fold selectivity for ROCK over other kinases, making it an invaluable tool for research applications related to cellular signaling, cytoskeletal dynamics, and the study of various pathological conditions, including cancer and cardiovascular diseases. Researchers can utilize ROCK-IN-10 to investigate the role of ROCK in cellular processes and to explore potential therapeutic strategies targeting these kinases. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
