Product Data Sheet
SB772077B
Catalog No. A36837
SB772077B is a selective inhibitor of Rho-associated protein kinase (ROCK), primarily targeting the RhoA/ROCK signaling pathway. This compound exhibits anti-inflammatory properties and enhances aqueous outflow facility, making it relevant for research in glaucoma. Additionally, SB772077B reduces mRNA levels of β-catenin and proteins associated with fibrosis, such as vinculin, fibronectin, collagen 1A, and vimentin. Furthermore, it demonstrates vasodilatory effects and lowers both pulmonary and systemic blood pressure, contributing to its utility in studies related to pulmonary hypertensive disorders.
Chemical Information
| Catalog Num | A36837 |
|---|---|
| M. Wt | 342.36 |
| Formula | C15H18N8O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 785774-34-7 |
| Synonyms | |
| SMILES | NC1=NON=C1C(N2CC)=NC3=C2C(C(N4C[C@@H](N)CC4)=O)=CN=C3 |
Biological Activity
| Description | SB772077B is a selective inhibitor of Rho-associated protein kinase (ROCK), primarily targeting the RhoA/ROCK signaling pathway. This compound exhibits anti-inflammatory properties and enhances aqueous outflow facility, making it relevant for research in glaucoma. Additionally, SB772077B reduces mRNA levels of β-catenin and proteins associated with fibrosis, such as vinculin, fibronectin, collagen 1A, and vimentin. Furthermore, it demonstrates vasodilatory effects and lowers both pulmonary and systemic blood pressure, contributing to its utility in studies related to pulmonary hypertensive disorders. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
