Product Data Sheet
ROCK2-IN-5
Catalog No. A36844
ROCK2-IN-5 is a selective inhibitor of Rho-associated protein kinase 2 (ROCK2), designed to modulate various cellular pathways implicated in neurodegenerative disorders. This compound exhibits a multitarget profile, integrating structural features from the Rho kinase inhibitor fasudil and the NRF2 inducers caffeic and ferulic acids. ROCK2-IN-5 shows promise in the investigation of amyotrophic lateral sclerosis (ALS), particularly concerning SOD1 mutations, by potentially mitigating cellular stress responses and neuroinflammation associated with the disease.
Chemical Information
| Catalog Num | A36844 |
|---|---|
| M. Wt | 455.53 |
| Formula | C23H25N3O5S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3031515-48-4 |
| Synonyms | |
| SMILES | O=C(CCC1=CC(O)=C(C=C1)O)N2CCCN(S(C3=C4C(C=NC=C4)=CC=C3)(=O)=O)CC2 |
Biological Activity
| Description | ROCK2-IN-5 is a selective inhibitor of Rho-associated protein kinase 2 (ROCK2), designed to modulate various cellular pathways implicated in neurodegenerative disorders. This compound exhibits a multitarget profile, integrating structural features from the Rho kinase inhibitor fasudil and the NRF2 inducers caffeic and ferulic acids. ROCK2-IN-5 shows promise in the investigation of amyotrophic lateral sclerosis (ALS), particularly concerning SOD1 mutations, by potentially mitigating cellular stress responses and neuroinflammation associated with the disease. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
