Product Data Sheet
LASSBio-2389
Catalog No. A36848
LASSBio-2389 is a selective inhibitor of Rho-associated protein kinase 2 (ROCK2) with an IC50 of 0.051 μM and demonstrates lower potency against ROCK1 with an IC50 of 1.143 μM. This compound effectively reduces the viability of MDA-MB-231 cells and inhibits cell migration, making it a valuable tool for investigating the pathophysiology of triple-negative breast cancer. Its targeted action on ROCK2 positions LASSBio-2389 as a significant reagent in cancer research applications focused on aggressive tumor behaviors.
Chemical Information
| Catalog Num | A36848 |
|---|---|
| M. Wt | 354.36 |
| Formula | C18H18N4O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2671377-38-9 |
| Synonyms | |
| SMILES | O=C(C1=CC(OC)=C(OC)C(OC)=C1)N/N=C/C2=CC(C=NN3)=C3C=C2 |
Biological Activity
| Description | LASSBio-2389 is a selective inhibitor of Rho-associated protein kinase 2 (ROCK2) with an IC50 of 0.051 μM and demonstrates lower potency against ROCK1 with an IC50 of 1.143 μM. This compound effectively reduces the viability of MDA-MB-231 cells and inhibits cell migration, making it a valuable tool for investigating the pathophysiology of triple-negative breast cancer. Its targeted action on ROCK2 positions LASSBio-2389 as a significant reagent in cancer research applications focused on aggressive tumor behaviors. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
