Product Data Sheet
ROCK2-IN-14
Catalog No. A36850
ROCK2-IN-14 is a selective inhibitor of ROCK2, exhibiting an IC50 of 4.8 nM and 212-fold selectivity over ROCK1. This compound inhibits the ROCK2/S100A9 signaling pathway, leading to downregulation of S100A9 expression, inhibition of NM2 phosphorylation, and restoration of cytoskeletal abnormalities. It demonstrates significant anti-inflammatory effects, including the reduction of cytokines such as IgE, TNF-α, IL-6, and TSLP, and is effective in mitigating ear thickening in mouse models of atopic dermatitis. ROCK2-IN-14 is suitable for studies focused on inflammation and skin disorders.
Chemical Information
| Catalog Num | A36850 |
|---|---|
| M. Wt | 434.55 |
| Formula | C24H26N4O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3115784-59-0 |
| Synonyms | |
| SMILES | CN(C)CCCOC1=CC(CNC(C2=CC3=CC=C(C4=CNN=C4)C=C3S2)=O)=CC=C1 |
Biological Activity
| Description | ROCK2-IN-14 is a selective inhibitor of ROCK2, exhibiting an IC50 of 4.8 nM and 212-fold selectivity over ROCK1. This compound inhibits the ROCK2/S100A9 signaling pathway, leading to downregulation of S100A9 expression, inhibition of NM2 phosphorylation, and restoration of cytoskeletal abnormalities. It demonstrates significant anti-inflammatory effects, including the reduction of cytokines such as IgE, TNF-α, IL-6, and TSLP, and is effective in mitigating ear thickening in mouse models of atopic dermatitis. ROCK2-IN-14 is suitable for studies focused on inflammation and skin disorders. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
