Product Data Sheet
Ripasudil free base
Catalog No. A36857
Ripasudil free base is a selective inhibitor of Rho-associated protein kinase (ROCK), demonstrating IC50 values of 19 nM for ROCK2 and 51 nM for ROCK1. This compound exhibits significant biological activity in modulating cellular processes such as migration and proliferation, making it valuable in research focused on fibrosis, cancer, and cardiovascular diseases. Ripasudil free base is an important tool for studies investigating the role of ROCK signaling in various physiological and pathological contexts.
Chemical Information
| Catalog Num | A36857 |
|---|---|
| M. Wt | 323.39 |
| Formula | C15H18FN3O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 223645-67-8 |
| Synonyms | K-115 free base |
| SMILES | FC1=CN=CC2=C1C(S(N3CCCNC[C@@H]3C)(=O)=O)=CC=C2 |
Biological Activity
| Description | Ripasudil free base is a selective inhibitor of Rho-associated protein kinase (ROCK), demonstrating IC50 values of 19 nM for ROCK2 and 51 nM for ROCK1. This compound exhibits significant biological activity in modulating cellular processes such as migration and proliferation, making it valuable in research focused on fibrosis, cancer, and cardiovascular diseases. Ripasudil free base is an important tool for studies investigating the role of ROCK signaling in various physiological and pathological contexts. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
