Product Data Sheet
PI-828
Catalog No. A36878
PI-828 is a dual inhibitor of phosphoinositide 3-kinase (PI3K) and casein kinase 2 (CK2), exhibiting IC50 values of 173 nM for p110α, 149 nM for CK2, and 1127 nM for CK2α2 in lipid kinase assays. This compound demonstrates significant biological activity by modulating key signaling pathways involved in cell growth and survival. PI-828 is utilized in research applications focused on cancer biology, providing insights into tumorigenesis and potential therapeutic interventions targeting these kinases.
Chemical Information
| Catalog Num | A36878 |
|---|---|
| M. Wt | 322.36 |
| Formula | C19H18N2O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 942289-87-4 |
| Synonyms | |
| SMILES | O=C1C=C(N2CCOCC2)OC3=C(C4=CC=C(N)C=C4)C=CC=C13 |
Biological Activity
| Description | PI-828 is a dual inhibitor of phosphoinositide 3-kinase (PI3K) and casein kinase 2 (CK2), exhibiting IC50 values of 173 nM for p110α, 149 nM for CK2, and 1127 nM for CK2α2 in lipid kinase assays. This compound demonstrates significant biological activity by modulating key signaling pathways involved in cell growth and survival. PI-828 is utilized in research applications focused on cancer biology, providing insights into tumorigenesis and potential therapeutic interventions targeting these kinases. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
