Product Data Sheet
INNO-220
Catalog No. A36893
INNO-220 is a CRBN-dependent molecular glue degrader that specifically targets CK1α. This orally active compound induces cell cycle arrest at the G0/G1 phase and promotes apoptosis through the degradation of CK1α. Additionally, INNO-220 disrupts the assembly and function of the CARD11/BCL10/MALT1 complex, effectively inhibiting NF-κB signaling in stimulated T cells and lymphoma cells with activating mutations in CARD11. This reagent serves as a valuable tool for advancing research in lymphoma.
Chemical Information
| Catalog Num | A36893 |
|---|---|
| M. Wt | 400.43 |
| Formula | C23H20N4O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3032576-92-1 |
| Synonyms | |
| SMILES | CN1N=CC(C2=CC3=C(C(N(C3)C4CCC(NC4=O)=O)=O)C=C2)=C1C5=CC=CC=C5 |
Biological Activity
| Description | INNO-220 is a CRBN-dependent molecular glue degrader that specifically targets CK1α. This orally active compound induces cell cycle arrest at the G0/G1 phase and promotes apoptosis through the degradation of CK1α. Additionally, INNO-220 disrupts the assembly and function of the CARD11/BCL10/MALT1 complex, effectively inhibiting NF-κB signaling in stimulated T cells and lymphoma cells with activating mutations in CARD11. This reagent serves as a valuable tool for advancing research in lymphoma. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
