Product Data Sheet
SR-1277
Catalog No. A36902
SR-1277 is a potent and selective inhibitor of casein kinase 1 delta (CK1δ) and epsilon (CK1ε), demonstrating ATP-competitive inhibition with IC50 values of 49 nM and 260 nM, respectively. Additionally, it exhibits inhibitory effects on FLT3, CDK4/cyclin D1, CDK6/cyclin D3, and CDK9/cyclin K, with IC50 values of 305 nM, 1340 nM, 311 nM, and 109 nM, respectively. SR-1277 is primarily employed in cancer research, contributing to studies investigating CK1-mediated signaling pathways and therapeutic potential.
Chemical Information
| Catalog Num | A36902 |
|---|---|
| M. Wt | 477.50 |
| Formula | C21H19N9O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1446715-47-4 |
| Synonyms | |
| SMILES | O=[N+](C1=C2C(N=C(CNC3=C4N=CN(C5=CSC=C5)C4=NC(N6CCOCC6)=N3)N2)=CC=C1)[O-] |
Biological Activity
| Description | SR-1277 is a potent and selective inhibitor of casein kinase 1 delta (CK1δ) and epsilon (CK1ε), demonstrating ATP-competitive inhibition with IC50 values of 49 nM and 260 nM, respectively. Additionally, it exhibits inhibitory effects on FLT3, CDK4/cyclin D1, CDK6/cyclin D3, and CDK9/cyclin K, with IC50 values of 305 nM, 1340 nM, 311 nM, and 109 nM, respectively. SR-1277 is primarily employed in cancer research, contributing to studies investigating CK1-mediated signaling pathways and therapeutic potential. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
