Product Data Sheet
SR-4133
Catalog No. A36923
SR-4133 is a selective inhibitor of Casein Kinase 1 epsilon (CK1ε) with an IC50 value of 58 nM. This compound binds effectively to the ATP-binding site of CK1ε, leading to significant inhibition of cell growth in bladder cancer models at nanomolar concentrations. Additionally, SR-4133 disrupts the phosphorylation of 4E-BP1, making it valuable for research applications in cancer biology and signaling pathways.
Chemical Information
| Catalog Num | A36923 |
|---|---|
| M. Wt | 512.51 |
| Formula | C27H22F2N8O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2999645-23-5 |
| Synonyms | |
| SMILES | FC1=C(F)C2=C(NC(CNC3=NC(N4CCOCC4)=NC5=C3N=CN5C6=CC(C=CC=C7)=C7C=C6)=N2)C=C1 |
Biological Activity
| Description | SR-4133 is a selective inhibitor of Casein Kinase 1 epsilon (CK1ε) with an IC50 value of 58 nM. This compound binds effectively to the ATP-binding site of CK1ε, leading to significant inhibition of cell growth in bladder cancer models at nanomolar concentrations. Additionally, SR-4133 disrupts the phosphorylation of 4E-BP1, making it valuable for research applications in cancer biology and signaling pathways. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
