Product Data Sheet
BMS-135
Catalog No. A36938
BMS-135 is a potent and selective ATP-competitive inhibitor of casein kinase 2 (CK2), demonstrating IC50 values of 0.8 nM and 0.3 nM for the CK2α and CK2α′ isoforms, respectively. By mimicking ATP, BMS-135 effectively binds to the active site of CK2, inhibiting its serine/threonine phosphorylation activity. This inhibition results in the suppression of cellular proliferation and exhibits anti-tumor properties. BMS-135 is particularly relevant for research applications in colon cancer studies.
Chemical Information
| Catalog Num | A36938 |
|---|---|
| M. Wt | 510.94 |
| Formula | C22H23ClN10O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1541248-36-5 |
| Synonyms | |
| SMILES | N#CC1=CN=C2N1N=C(N=C2NCC)NC3=C(C(N4C[C@H]([C@@H](CC4)NC(OC)=O)O)=CC(C#N)=C3)Cl |
Biological Activity
| Description | BMS-135 is a potent and selective ATP-competitive inhibitor of casein kinase 2 (CK2), demonstrating IC50 values of 0.8 nM and 0.3 nM for the CK2α and CK2α′ isoforms, respectively. By mimicking ATP, BMS-135 effectively binds to the active site of CK2, inhibiting its serine/threonine phosphorylation activity. This inhibition results in the suppression of cellular proliferation and exhibits anti-tumor properties. BMS-135 is particularly relevant for research applications in colon cancer studies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
