Product Data Sheet
Poricoic acid A
Catalog No. A36985
Poricoic acid A is a natural product derived from Poria cocos, exhibiting oral bioactivity as an anti-tumor agent. This compound plays a significant role in attenuating renal fibrosis by modulating the Gas6/Axl-NFκB/Nrf2 signaling pathway and activating AMPK while inhibiting Smad3, thus reducing fibroblast activation and abnormal extracellular matrix remodeling. Additionally, Poricoic acid A, in conjunction with Melatonin, has been shown to mitigate oxidative stress and inflammation, improving renal function and decreasing serum creatinine and urea levels in rodent models of ischemia-reperfusion injury. This highlights its potential in renal protection and cancer research applications.
Chemical Information
| Catalog Num | A36985 |
|---|---|
| M. Wt | 498.69 |
| Formula | C31H46O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 137551-38-3 |
| Synonyms | Poricoic acid A(F) |
| SMILES | C[C@]12[C@@]([C@]([C@H](C(O)=O)CCC(C(C)C)=C)([H])[C@H](O)C1)(CC=C3C2=CC[C@@H](C(C)=C)[C@]3(C)CCC(O)=O)C |
Biological Activity
| Description | Poricoic acid A is a natural product derived from Poria cocos, exhibiting oral bioactivity as an anti-tumor agent. This compound plays a significant role in attenuating renal fibrosis by modulating the Gas6/Axl-NFκB/Nrf2 signaling pathway and activating AMPK while inhibiting Smad3, thus reducing fibroblast activation and abnormal extracellular matrix remodeling. Additionally, Poricoic acid A, in conjunction with Melatonin, has been shown to mitigate oxidative stress and inflammation, improving renal function and decreasing serum creatinine and urea levels in rodent models of ischemia-reperfusion injury. This highlights its potential in renal protection and cancer research applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
