Product Data Sheet
MORF-627
Catalog No. A37012
MORF-627 is a selective integrin αvβ6 inhibitor that effectively impairs TGF-β1 activation and pSMAD2 signaling. This compound significantly decreases collagen deposition and markers of epithelial-mesenchymal transition in fibrotic cells, demonstrating notable antifibrotic activity in idiopathic pulmonary fibrosis models without causing genotoxicity. While MORF-627 induces bladder epithelial proliferation and early invasive urothelial carcinoma in cynomolgus monkeys and human cells, these toxic effects can be mitigated by exogenous TGF-β. This reagent is valuable for investigating the pathological mechanisms underlying pulmonary fibrosis and assessing associated drug safety.
Chemical Information
| Catalog Num | A37012 |
|---|---|
| M. Wt | 537.67 |
| Formula | C31H40FN3O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2412688-16-3 |
| Synonyms | |
| SMILES | OC([C@@H](N1C[C@@H](CC1)OCCCCC(N2)=CC=C3C2=NCCC3)C4=C(C=CC(F)=C4)[C@@H]5CCC6(CO5)CC6)=O |
Biological Activity
| Description | MORF-627 is a selective integrin αvβ6 inhibitor that effectively impairs TGF-β1 activation and pSMAD2 signaling. This compound significantly decreases collagen deposition and markers of epithelial-mesenchymal transition in fibrotic cells, demonstrating notable antifibrotic activity in idiopathic pulmonary fibrosis models without causing genotoxicity. While MORF-627 induces bladder epithelial proliferation and early invasive urothelial carcinoma in cynomolgus monkeys and human cells, these toxic effects can be mitigated by exogenous TGF-β. This reagent is valuable for investigating the pathological mechanisms underlying pulmonary fibrosis and assessing associated drug safety. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
