Product Data Sheet
AN02
Catalog No. A37044
AN02 is a CTLA-4 degrader that demonstrates potent anti-cancer activity in ovarian cancer research. This compound inhibits cell proliferation, clonogenicity, migration, and invasion of ovarian cancer cells while upregulating the expression of antigen-presenting cells (APC). AN02 mediates CTLA-4 degradation through the SMAD4 pathway, significantly reducing tumor growth in small xenograft models and reversing the immune-suppressive tumor environment. Additionally, when used in combination with Ipilimumab, AN02 enhances therapeutic efficacy and inhibits epithelial-mesenchymal transition, making it a valuable tool for studying ovarian cancer.
Chemical Information
| Catalog Num | A37044 |
|---|---|
| M. Wt | 344.23 |
| Formula | C19H15Cl2NO |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1246964-08-8 |
| Synonyms | |
| SMILES | ClC1=CC=CC=C1/C=C(C/2=O)\CNCC2=C/C3=C(Cl)C=CC=C3 |
Biological Activity
| Description | AN02 is a CTLA-4 degrader that demonstrates potent anti-cancer activity in ovarian cancer research. This compound inhibits cell proliferation, clonogenicity, migration, and invasion of ovarian cancer cells while upregulating the expression of antigen-presenting cells (APC). AN02 mediates CTLA-4 degradation through the SMAD4 pathway, significantly reducing tumor growth in small xenograft models and reversing the immune-suppressive tumor environment. Additionally, when used in combination with Ipilimumab, AN02 enhances therapeutic efficacy and inhibits epithelial-mesenchymal transition, making it a valuable tool for studying ovarian cancer. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
