Product Data Sheet
NRX-252114
Catalog No. A37056
NRX-252114 is a potent enhancer of the β-catenin:β-TrCP interaction, facilitating the binding of phosphorylated β-catenin peptides to the E3 ubiquitin ligase SCFβ-TrCP. With an EC50 of 6.5 nM and a Kd of 0.4 nM, this compound significantly boosts the degradation of mutant β-catenin. NRX-252114 is useful in research applications focused on the Wnt signaling pathway and its implications in cancer biology and developmental processes.
Chemical Information
| Catalog Num | A37056 |
|---|---|
| M. Wt | 510.32 |
| Formula | C22H12Cl2F3N3O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2763260-39-3 |
| Synonyms | |
| SMILES | N#CC1=CC=CC2=C1CN(C(C3=C(SC4=C(Cl)C=CC=C4Cl)C=C(C(F)(F)F)NC3=O)=O)C2 |
Biological Activity
| Description | NRX-252114 is a potent enhancer of the β-catenin:β-TrCP interaction, facilitating the binding of phosphorylated β-catenin peptides to the E3 ubiquitin ligase SCFβ-TrCP. With an EC50 of 6.5 nM and a Kd of 0.4 nM, this compound significantly boosts the degradation of mutant β-catenin. NRX-252114 is useful in research applications focused on the Wnt signaling pathway and its implications in cancer biology and developmental processes. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
