Product Data Sheet
NRX-103094
Catalog No. A37057
NRX-103094 is an enhancer of the β-catenin:β-TrCP interaction, specifically targeting the binding of phospho-Ser33/Ser37 β-catenin to its E3 ligase, SCFβ-TrCP. With an EC50 of 62 nM and a Kd of 0.6 nM, NRX-103094 facilitates this critical protein-protein interaction, making it a valuable tool for research into Wnt signaling pathways and related cellular processes. Its ability to modulate β-catenin stability can aid investigations into various aspects of cellular biology, including cancer research and developmental biology.
Chemical Information
| Catalog Num | A37057 |
|---|---|
| M. Wt | 503.28 |
| Formula | C20H11Cl2F3N2O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2763260-36-0 |
| Synonyms | |
| SMILES | OC(C1=CC=CC(NC(C2=C(C=C(NC2=O)C(F)(F)F)SC3=C(C=CC=C3Cl)Cl)=O)=C1)=O |
Biological Activity
| Description | NRX-103094 is an enhancer of the β-catenin:β-TrCP interaction, specifically targeting the binding of phospho-Ser33/Ser37 β-catenin to its E3 ligase, SCFβ-TrCP. With an EC50 of 62 nM and a Kd of 0.6 nM, NRX-103094 facilitates this critical protein-protein interaction, making it a valuable tool for research into Wnt signaling pathways and related cellular processes. Its ability to modulate β-catenin stability can aid investigations into various aspects of cellular biology, including cancer research and developmental biology. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
