Product Data Sheet
NRX-2663
Catalog No. A37072
NRX-2663 is an enhancer of the β-catenin:β-TrCP interaction, specifically targeting the binding of β-catenin to its E3 ubiquitin ligase, SCFβ-TrCP. This compound improves the affinity of β-catenin peptides for β-TrCP, demonstrating an EC50 of 22.9 μM and a Kd of 54.8 nM. NRX-2663 is valuable for research into the regulation of the Wnt signaling pathway and its implications in various cancers and developmental processes.
Chemical Information
| Catalog Num | A37072 |
|---|---|
| M. Wt | 418.32 |
| Formula | C20H13F3N2O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2763260-34-8 |
| Synonyms | |
| SMILES | OC(C1=CC=CC(NC(C2=C(C=C(NC2=O)C(F)(F)F)OC3=CC=CC=C3)=O)=C1)=O |
Biological Activity
| Description | NRX-2663 is an enhancer of the β-catenin:β-TrCP interaction, specifically targeting the binding of β-catenin to its E3 ubiquitin ligase, SCFβ-TrCP. This compound improves the affinity of β-catenin peptides for β-TrCP, demonstrating an EC50 of 22.9 μM and a Kd of 54.8 nM. NRX-2663 is valuable for research into the regulation of the Wnt signaling pathway and its implications in various cancers and developmental processes. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
