Product Data Sheet
Arimoclomol
Catalog No. A37464
Arimoclomol is an orally active co-inducer of heat shock proteins (HSP). It functions by enhancing Hsp expression, thereby providing protection to motor neurons through the modulation of protein aggregation and promoting the clearance of misfolded proteins via the proteasome-ubiquitin system. This compound is particularly relevant for research applications concerning Niemann-Pick disease type C, as it effectively crosses the blood-brain barrier, facilitating its therapeutic potential in neurological disorders.
Chemical Information
| Catalog Num | A37464 |
|---|---|
| M. Wt | 313.78 |
| Formula | C14H20ClN3O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 289893-25-0 |
| Synonyms | BRX-220 free base |
| SMILES | Cl/C(C1=C[N+]([O-])=CC=C1)=N\OC[C@H](O)CN2CCCCC2 |
Biological Activity
| Description | Arimoclomol is an orally active co-inducer of heat shock proteins (HSP). It functions by enhancing Hsp expression, thereby providing protection to motor neurons through the modulation of protein aggregation and promoting the clearance of misfolded proteins via the proteasome-ubiquitin system. This compound is particularly relevant for research applications concerning Niemann-Pick disease type C, as it effectively crosses the blood-brain barrier, facilitating its therapeutic potential in neurological disorders. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
