Product Data Sheet
Rosolutamide
Catalog No. A37470
Rosolutamide is a potent Nrf1 and Nrf2 activator that enhances the expression of proteasome subunits, antioxidant enzymes, and molecular chaperones through the activation of these transcription factors. This curcumin analog facilitates the degradation of polyglutamine (polyQ) androgen receptors via the ubiquitin-proteasome pathway, thereby improving motor function in mouse models of spinal and bulbar muscular atrophy (SBMA). Additionally, Rosolutamide promotes mitochondrial function, autophagy, and reduces intracellular and mitochondrial reactive oxygen species (ROS) levels, making it a valuable tool for research exploring neurodegenerative diseases and oxidative stress.
Chemical Information
| Catalog Num | A37470 |
|---|---|
| M. Wt | 464.55 |
| Formula | C28H32O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1039760-91-2 |
| Synonyms | ASC-JM17; ALZ-003 |
| SMILES | COC(C=C1/C=C/C(C(C(/C=C/C2=CC(OC)=C(C=C2)OC)=O)CC3CCC3)=O)=C(C=C1)OC |
Biological Activity
| Description | Rosolutamide is a potent Nrf1 and Nrf2 activator that enhances the expression of proteasome subunits, antioxidant enzymes, and molecular chaperones through the activation of these transcription factors. This curcumin analog facilitates the degradation of polyglutamine (polyQ) androgen receptors via the ubiquitin-proteasome pathway, thereby improving motor function in mouse models of spinal and bulbar muscular atrophy (SBMA). Additionally, Rosolutamide promotes mitochondrial function, autophagy, and reduces intracellular and mitochondrial reactive oxygen species (ROS) levels, making it a valuable tool for research exploring neurodegenerative diseases and oxidative stress. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
