Product Data Sheet
BMS-358233
Catalog No. A37575
BMS-358233 is a small molecule inhibitor targeting heat shock protein 90 (Hsp90). By competing with geldanamycin, BMS-358233 induces the degradation of various proteins, including HER2, leading to the inhibition of breast cancer cell growth. This compound causes hypophosphorylation of the retinoblastoma protein, resulting in G1 phase cell cycle arrest and differentiation. BMS-358233 represents a novel class of synthetic Hsp90 inhibitors, offering potential therapeutic strategies for treating various cancers.
Chemical Information
| Catalog Num | A37575 |
|---|---|
| M. Wt | 509.02 |
| Formula | C25H25ClN6O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 601519-75-9 |
| Synonyms | |
| SMILES | O=C(C1=CC=C2N=C(NC3=NC(NC[C@@H]4OCCC4)=NC(C)=C3)SC2=C1)NC5=C(C)C=CC=C5Cl |
Biological Activity
| Description | BMS-358233 is a small molecule inhibitor targeting heat shock protein 90 (Hsp90). By competing with geldanamycin, BMS-358233 induces the degradation of various proteins, including HER2, leading to the inhibition of breast cancer cell growth. This compound causes hypophosphorylation of the retinoblastoma protein, resulting in G1 phase cell cycle arrest and differentiation. BMS-358233 represents a novel class of synthetic Hsp90 inhibitors, offering potential therapeutic strategies for treating various cancers. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
