Product Data Sheet
(+)-Rocaglamide (d-Rocaglamide)
Catalog No. A37578
(+)–Rocaglamide is a selective inhibitor of heat shock factor 1 (HSF1), exhibiting an IC50 value of 50 nM. It is effective in inhibiting NF-κB activation in T-cells and the activity of the translation initiation factor eIF4A. Research applications include its potential use in anti-inflammatory treatments and as an anticancer agent, particularly against leukemia. This compound is derived from the genus Aglaia and demonstrates promising therapeutic properties for various conditions, including inflammatory diseases.
Chemical Information
| Catalog Num | A37578 |
|---|---|
| M. Wt | 505.56 |
| Formula | C29H31NO7 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1699754-37-4 |
| Synonyms | |
| SMILES | O[C@@]12[C@@](OC3=CC(OC)=CC(OC)=C32)(C4=CC=C(C=C4)OC)[C@@H](C5=CC=CC=C5)[C@@H]([C@@H]1O)C(N(C)C)=O |
Biological Activity
| Description | (+)–Rocaglamide is a selective inhibitor of heat shock factor 1 (HSF1), exhibiting an IC50 value of 50 nM. It is effective in inhibiting NF-κB activation in T-cells and the activity of the translation initiation factor eIF4A. Research applications include its potential use in anti-inflammatory treatments and as an anticancer agent, particularly against leukemia. This compound is derived from the genus Aglaia and demonstrates promising therapeutic properties for various conditions, including inflammatory diseases. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
