Product Data Sheet
KU-177
Catalog No. A37585
KU-177 is an effective disruptor of the Aha1/Hsp90 complex. It inhibits Aha1-driven enhancement of Hsp90-dependent tau aggregation, demonstrating an IC50 of 4.08 μM in disrupting Aha1/Hsp90 interactions without affecting Hsp90's ATPase activity. This compound is applicable in research focused on tauopathies, providing valuable insights into neurodegenerative processes.
Chemical Information
| Catalog Num | A37585 |
|---|---|
| M. Wt | 489.47 |
| Formula | C27H23NO8 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1160952-43-1 |
| Synonyms | |
| SMILES | COC1=CC(C2=C(C=CC(C(NC3=CC4=CC=C(C(OC)=C4OC3=O)OC(C)=O)=O)=C2)OC)=CC=C1 |
Biological Activity
| Description | KU-177 is an effective disruptor of the Aha1/Hsp90 complex. It inhibits Aha1-driven enhancement of Hsp90-dependent tau aggregation, demonstrating an IC50 of 4.08 μM in disrupting Aha1/Hsp90 interactions without affecting Hsp90's ATPase activity. This compound is applicable in research focused on tauopathies, providing valuable insights into neurodegenerative processes. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
