Product Data Sheet
Onradivir
Catalog No. A37699
Onradivir is an orally active antiviral agent that specifically targets the PB2 subunit of influenza A virus RNA polymerase, exhibiting an IC50 of 0.562 nM. By inhibiting cap binding, Onradivir effectively suppresses viral replication, lowers viral titers, and mitigates influenza A virus infection. In preclinical studies, Onradivir demonstrated enhanced survival rates in mice infected with influenza A virus and significantly reduced viral loads. This compound is valuable for researching influenza A virus infections and developing potential therapeutic strategies.
Chemical Information
| Catalog Num | A37699 |
|---|---|
| M. Wt | 440.45 |
| Formula | C22H22F2N6O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2200336-20-3 |
| Synonyms | ZSP1273 |
| SMILES | FC1=CN=C2C(C(C3=NC(N[C@@H]4[C@H](C5CCC4CC5)C(O)=O)=C(F)C(C6CC6)=N3)=NN2)=C1 |
Biological Activity
| Description | Onradivir is an orally active antiviral agent that specifically targets the PB2 subunit of influenza A virus RNA polymerase, exhibiting an IC50 of 0.562 nM. By inhibiting cap binding, Onradivir effectively suppresses viral replication, lowers viral titers, and mitigates influenza A virus infection. In preclinical studies, Onradivir demonstrated enhanced survival rates in mice infected with influenza A virus and significantly reduced viral loads. This compound is valuable for researching influenza A virus infections and developing potential therapeutic strategies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
