Product Data Sheet
8-Bromo-2'-deoxyguanosine
Catalog No. A37876
8-Bromo-2'-deoxyguanosine is a halogenated DNA adduct associated with inflammation, serving as an early biomarker for oxidative tissue damage linked to inflammatory processes. Its formation precedes the generation of other oxidative and nitrative stress products and can be synthesized through the MPO-H2O2-Cl−-Br− system. This compound plays a critical role in detecting early DNA modifications using the monoclonal antibody mAb8B3, suitable for preclinical research. Additionally, its urinary levels are significantly elevated in various inflammatory disease models, making 8-Bromo-2'-deoxyguanosine valuable for investigations into inflammatory diseases, diabetes, hepatocellular carcinoma, and UV-B induced skin injuries.
Chemical Information
| Catalog Num | A37876 |
|---|---|
| M. Wt | 346.14 |
| Formula | C10H12BrN5O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 13389-03-2 |
| Synonyms | |
| SMILES | OC[C@@H]1[C@@H](O)C[C@H](N2C(Br)=NC3=C2N=C(N)NC3=O)O1 |
Biological Activity
| Description | 8-Bromo-2'-deoxyguanosine is a halogenated DNA adduct associated with inflammation, serving as an early biomarker for oxidative tissue damage linked to inflammatory processes. Its formation precedes the generation of other oxidative and nitrative stress products and can be synthesized through the MPO-H2O2-Cl−-Br− system. This compound plays a critical role in detecting early DNA modifications using the monoclonal antibody mAb8B3, suitable for preclinical research. Additionally, its urinary levels are significantly elevated in various inflammatory disease models, making 8-Bromo-2'-deoxyguanosine valuable for investigations into inflammatory diseases, diabetes, hepatocellular carcinoma, and UV-B induced skin injuries. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
