Product Data Sheet
aTAG 4531
Catalog No. A38067
aTAG 4531 is a selective MTH1 degrader that exerts its action through the formation of a ternary complex with MTH1, CRBN E3 ligase, and the degrader itself. It displays a DC50 value of 0.28 nM and a Ki value of 1.8 nM, highlighting its potent degradation capability. This compound is valuable for research focused on MTH1 inhibition and subsequent cellular effects, offering insights into its role in cancer biology and related therapeutic applications.
Chemical Information
| Catalog Num | A38067 |
|---|---|
| M. Wt | 867.85 |
| Formula | C46H39F2N9O7 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2412985-00-1 |
| Synonyms | CFT-4531 |
| SMILES | O=C(C1=C(F)C=C(C2=CC3=C(NC4=CC=CC=C4)C(C(NC5CC5)=O)=CN=C3C=C2F)C=C1)NCCCCN6N=NC(COC7=CC=CC(C(N8C9C(NC(CC9)=O)=O)=O)=C7C8=O)=C6 |
Biological Activity
| Description | aTAG 4531 is a selective MTH1 degrader that exerts its action through the formation of a ternary complex with MTH1, CRBN E3 ligase, and the degrader itself. It displays a DC50 value of 0.28 nM and a Ki value of 1.8 nM, highlighting its potent degradation capability. This compound is valuable for research focused on MTH1 inhibition and subsequent cellular effects, offering insights into its role in cancer biology and related therapeutic applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
