Product Data Sheet
IACS-4619
Catalog No. A38267
IACS-4619 is a highly selective inhibitor of the MTH1 enzyme (MutT homolog 1) with an IC50 of 0.2 nM. This 2-aminopyrimidine compound effectively blocks the hydrolysis of oxidized purine nucleotides, such as 8-oxo-dGTP, preventing the incorporation of these nucleotides into DNA. Notably, IACS-4619 demonstrates significant inhibition of endogenous MTH1 activity in MTH1-overexpressing U2OS cells without exhibiting antiproliferative or cytotoxic effects on various human cancer and normal cell lines. This reagent is applicable in oncology research targeting the MTH1 pathway.
Chemical Information
| Catalog Num | A38267 |
|---|---|
| M. Wt | 195.27 |
| Formula | C10H17N3O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1884209-98-6 |
| Synonyms | |
| SMILES | N=1C=C(C(=NC1N)OCC(C)(C)C)C |
Biological Activity
| Description | IACS-4619 is a highly selective inhibitor of the MTH1 enzyme (MutT homolog 1) with an IC50 of 0.2 nM. This 2-aminopyrimidine compound effectively blocks the hydrolysis of oxidized purine nucleotides, such as 8-oxo-dGTP, preventing the incorporation of these nucleotides into DNA. Notably, IACS-4619 demonstrates significant inhibition of endogenous MTH1 activity in MTH1-overexpressing U2OS cells without exhibiting antiproliferative or cytotoxic effects on various human cancer and normal cell lines. This reagent is applicable in oncology research targeting the MTH1 pathway. |
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Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
