Product Data Sheet
Nitracrine hydrochloride
Catalog No. A38515
Nitracrine hydrochloride is an RNA synthesis inhibitor that targets hypoxic cancer cells through its platinum-based structure. It demonstrates significant cytotoxicity against the Chinese hamster ovary cell line AA8 under low oxygen conditions, primarily by forming covalent adducts with DNA. This compound's mechanism involves reductive metabolism, leading to the formation of alkylating agents that enhance its reactivity with DNA. By inhibiting RNA synthesis, Nitracrine hydrochloride contributes to its overall anti-tumor efficacy, making it a valuable reagent for cancer research.
Chemical Information
| Catalog Num | A38515 |
|---|---|
| M. Wt | 360.84 |
| Formula | C18H21ClN4O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 6514-85-8 |
| Synonyms | |
| SMILES | O=[N+](C1=CC=CC2=NC3=CC=CC=C3C(NCCCN(C)C)=C21)[O-].Cl |
Biological Activity
| Description | Nitracrine hydrochloride is an RNA synthesis inhibitor that targets hypoxic cancer cells through its platinum-based structure. It demonstrates significant cytotoxicity against the Chinese hamster ovary cell line AA8 under low oxygen conditions, primarily by forming covalent adducts with DNA. This compound's mechanism involves reductive metabolism, leading to the formation of alkylating agents that enhance its reactivity with DNA. By inhibiting RNA synthesis, Nitracrine hydrochloride contributes to its overall anti-tumor efficacy, making it a valuable reagent for cancer research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
