Product Data Sheet
Cytarabine 5’-monophosphate
Catalog No. A38621
Cytarabine 5’-monophosphate is a DNA synthesis inhibitor that acts as a metabolite of the nucleoside analog Cytarabine. It is phosphorylated by deoxycytidine kinase and subsequently incorporated into DNA by DNA polymerase α, effectively reducing the rate of DNA synthesis. At a concentration of 15 mM, it shows inhibitory effects on nuclear and mitochondrial DNA replication in Saccharomyces cerevisiae. Additionally, at doses ranging from 3.5 to 75.1 mg/kg, it contributes to improved survival rates in L1210 leukemia mouse models, making it a valuable compound for cancer research applications.
Chemical Information
| Catalog Num | A38621 |
|---|---|
| M. Wt | 323.20 |
| Formula | C9H14N3O8P |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 7075-11-8 |
| Synonyms | |
| SMILES | O[C@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N2C(N=C(N)C=C2)=O |
Biological Activity
| Description | Cytarabine 5’-monophosphate is a DNA synthesis inhibitor that acts as a metabolite of the nucleoside analog Cytarabine. It is phosphorylated by deoxycytidine kinase and subsequently incorporated into DNA by DNA polymerase α, effectively reducing the rate of DNA synthesis. At a concentration of 15 mM, it shows inhibitory effects on nuclear and mitochondrial DNA replication in Saccharomyces cerevisiae. Additionally, at doses ranging from 3.5 to 75.1 mg/kg, it contributes to improved survival rates in L1210 leukemia mouse models, making it a valuable compound for cancer research applications. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
