Product Data Sheet
Taurolithocholic acid
Catalog No. A38796
Taurolithocholic acid is a bile acid recognized for its role as a ferroptosis suppressor. It activates the TGR5-PI3K/AKT-SREBP2 signaling pathway, leading to the upregulation of FADS2, which inhibits SFTSV-induced ferroptosis and viral replication, while also modulating pro-inflammatory cytokines such as IL-1β. In addition to its antiviral properties, taurolithocholic acid influences hepatocellular transport processes, promoting cholestatic effects. This compound serves as a valuable experimental model for studying hepatocellular cholestasis and provides insight into severe fever with thrombocytopenia syndrome without exhibiting cytotoxicity at concentrations ≤200 μM.
Chemical Information
| Catalog Num | A38796 |
|---|---|
| M. Wt | 483.70 |
| Formula | C26H45NO5S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 516-90-5 |
| Synonyms | |
| SMILES | C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(NCCS(=O)(O)=O)=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4([C@](C[C@@H](CC4)O)([H])CC3)C |
Biological Activity
| Description | Taurolithocholic acid is a bile acid recognized for its role as a ferroptosis suppressor. It activates the TGR5-PI3K/AKT-SREBP2 signaling pathway, leading to the upregulation of FADS2, which inhibits SFTSV-induced ferroptosis and viral replication, while also modulating pro-inflammatory cytokines such as IL-1β. In addition to its antiviral properties, taurolithocholic acid influences hepatocellular transport processes, promoting cholestatic effects. This compound serves as a valuable experimental model for studying hepatocellular cholestasis and provides insight into severe fever with thrombocytopenia syndrome without exhibiting cytotoxicity at concentrations ≤200 μM. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
