Product Data Sheet
PK11007
Catalog No. A38843
PK11007 is an anti-p53 agent that functions as a mild thiol alkylator, exhibiting significant anticancer activity. It selectively alkylates two surface-exposed cysteines on the p53 protein, leading to its stabilization without interfering with its DNA binding capabilities. Additionally, PK11007 promotes cell death in mutant p53 cancer cells by elevating reactive oxygen species (ROS) levels, making it a valuable compound for cancer research applications targeting p53 pathways.
Chemical Information
| Catalog Num | A38843 |
|---|---|
| M. Wt | 427.86 |
| Formula | C15H11ClFN5O3S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 874146-69-7 |
| Synonyms | |
| SMILES | O=C(C1=NC(S(=O)(CC2=CC=C(F)C=C2)=O)=NC=C1Cl)NC3=NN=C(C)S3 |
Biological Activity
| Description | PK11007 is an anti-p53 agent that functions as a mild thiol alkylator, exhibiting significant anticancer activity. It selectively alkylates two surface-exposed cysteines on the p53 protein, leading to its stabilization without interfering with its DNA binding capabilities. Additionally, PK11007 promotes cell death in mutant p53 cancer cells by elevating reactive oxygen species (ROS) levels, making it a valuable compound for cancer research applications targeting p53 pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
