Product Data Sheet
Swertiajaponin
Catalog No. A38926
Swertiajaponin is a potent tyrosinase inhibitor that interacts with the enzyme's binding pocket through hydrogen bonding and hydrophobic interactions, exhibiting an IC50 of 43.47 μM. It effectively inhibits oxidative stress-mediated MAPK/MITF signaling pathways, resulting in a reduction of tyrosinase protein levels. Additionally, Swertiajaponin demonstrates strong anti-oxidative activity and suppresses melanin accumulation, making it a valuable tool for research aimed at understanding pigmentation disorders and oxidative stress.
Chemical Information
| Catalog Num | A38926 |
|---|---|
| M. Wt | 462.40 |
| Formula | C22H22O11 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 6980-25-2 |
| Synonyms | |
| SMILES | O=C1C=C(C2=CC=C(O)C(O)=C2)OC3=CC(OC)=C([C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)C(O)=C13 |
Biological Activity
| Description | Swertiajaponin is a potent tyrosinase inhibitor that interacts with the enzyme's binding pocket through hydrogen bonding and hydrophobic interactions, exhibiting an IC50 of 43.47 μM. It effectively inhibits oxidative stress-mediated MAPK/MITF signaling pathways, resulting in a reduction of tyrosinase protein levels. Additionally, Swertiajaponin demonstrates strong anti-oxidative activity and suppresses melanin accumulation, making it a valuable tool for research aimed at understanding pigmentation disorders and oxidative stress. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
