Product Data Sheet
Succinyl phosphonate
Catalog No. A39019
Succinyl phosphonate is a selective inhibitor of α-ketoglutarate dehydrogenase (KGDHC) and 2-oxoglutarate dehydrogenase (OGDH). It effectively inhibits KGDHC activity in various cell types including muscle, bacterial, brain, and cultured human fibroblasts, demonstrating distinct effects on cell viability influenced by metabolic conditions in cancer cells. Additionally, succinyl phosphonate trisodium salt is known to reduce glutamate-induced reactive oxygen species (ROS) production in glutamate-stimulated hippocampal neurons, making it a valuable tool for studies in metabolic pathways and neurotoxicity.
Chemical Information
| Catalog Num | A39019 |
|---|---|
| M. Wt | 182.07 |
| Formula | C4H7O6P |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 26647-82-5 |
| Synonyms | |
| SMILES | O=C(O)CCC(P(O)(O)=O)=O |
Biological Activity
| Description | Succinyl phosphonate is a selective inhibitor of α-ketoglutarate dehydrogenase (KGDHC) and 2-oxoglutarate dehydrogenase (OGDH). It effectively inhibits KGDHC activity in various cell types including muscle, bacterial, brain, and cultured human fibroblasts, demonstrating distinct effects on cell viability influenced by metabolic conditions in cancer cells. Additionally, succinyl phosphonate trisodium salt is known to reduce glutamate-induced reactive oxygen species (ROS) production in glutamate-stimulated hippocampal neurons, making it a valuable tool for studies in metabolic pathways and neurotoxicity. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
