Product Data Sheet
IKKβ-IN-6
Catalog No. A39205
IKKβ-IN-6 is an antitumor agent that primarily targets IKKβ (IC50: 18.24 μM), effectively inhibiting its activity. This inhibition leads to reduced phosphorylation of p65 and IκBα, obstructing the nuclear translocation of p65 and modulating NF-κB-controlled gene expression. Additionally, IKKβ-IN-6 interacts with topoisomerase I, resulting in DNA damage, increased reactive oxygen species (ROS) levels, loss of mitochondrial membrane potential, and S-phase cell cycle arrest. This compound is particularly relevant for research focused on colorectal cancer.
Chemical Information
| Catalog Num | A39205 |
|---|---|
| M. Wt | 758.77 |
| Formula | C43H38N2O11 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3117527-91-7 |
| Synonyms | |
| SMILES | O=C(C([C@@H]1CC/C(COC(C2=CC=CC=C2C(OC3=CC4=CC5=C(N=C4C=C3)C6=CC7=C(C(N6C5)=O)COC([C@]7(O)CC)=O)=O)=O)=C\CC8)=C)O[C@@H]1[C@H]9O[C@@]98C |
Biological Activity
| Description | IKKβ-IN-6 is an antitumor agent that primarily targets IKKβ (IC50: 18.24 μM), effectively inhibiting its activity. This inhibition leads to reduced phosphorylation of p65 and IκBα, obstructing the nuclear translocation of p65 and modulating NF-κB-controlled gene expression. Additionally, IKKβ-IN-6 interacts with topoisomerase I, resulting in DNA damage, increased reactive oxygen species (ROS) levels, loss of mitochondrial membrane potential, and S-phase cell cycle arrest. This compound is particularly relevant for research focused on colorectal cancer. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
