Product Data Sheet
NEO214
Catalog No. A39475
NEO214 is an autophagy inhibitor that acts by preventing autophagy-lysosome fusion, effectively blocking autophagic flux. This compound, a covalent conjugate of the PDE4 inhibitor Rolipram and perillyl alcohol, exhibits anti-cancer activity and is capable of penetrating the blood-brain barrier. Its mechanism involves the activation of mTOR and aggregation of the transcription factor EB (TFEB), promoting the death of glioma cells. NEO214 may provide a strategy to combat chemotherapy resistance in glioblastoma.
Chemical Information
| Catalog Num | A39475 |
|---|---|
| M. Wt | 453.57 |
| Formula | C27H35NO5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1361198-80-2 |
| Synonyms | |
| SMILES | O=C(N1C(CC(C2=CC=C(OC)C(OC3CCCC3)=C2)C1)=O)OCC4=CC[C@@H](C(C)=C)CC4 |
Biological Activity
| Description | NEO214 is an autophagy inhibitor that acts by preventing autophagy-lysosome fusion, effectively blocking autophagic flux. This compound, a covalent conjugate of the PDE4 inhibitor Rolipram and perillyl alcohol, exhibits anti-cancer activity and is capable of penetrating the blood-brain barrier. Its mechanism involves the activation of mTOR and aggregation of the transcription factor EB (TFEB), promoting the death of glioma cells. NEO214 may provide a strategy to combat chemotherapy resistance in glioblastoma. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
