Product Data Sheet
SW063058
Catalog No. A39769
SW063058 is an autophagy inducer that selectively disrupts the interaction between Beclin 1 and Bcl-2, while preserving the binding of Bcl-2 to pro-apoptotic proteins such as Bax and BIM. This selective inhibition relieves the negative regulatory effects of Bcl-2 on Beclin 1, thereby enhancing autophagic activity. SW063058 promotes autophagy in vitro without inducing cytotoxicity, apoptosis, or other forms of cell death, making it a valuable tool for studying autophagic processes in various biological contexts.
Chemical Information
| Catalog Num | A39769 |
|---|---|
| M. Wt | 565.17 |
| Formula | C22H15BrFIN2O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 533876-30-1 |
| Synonyms | |
| SMILES | O=C1NC2=CC=C(C=C2C(N(C1)C(C3=C(I)C=CC=C3)=O)C4=CC=C(C=C4)F)Br |
Biological Activity
| Description | SW063058 is an autophagy inducer that selectively disrupts the interaction between Beclin 1 and Bcl-2, while preserving the binding of Bcl-2 to pro-apoptotic proteins such as Bax and BIM. This selective inhibition relieves the negative regulatory effects of Bcl-2 on Beclin 1, thereby enhancing autophagic activity. SW063058 promotes autophagy in vitro without inducing cytotoxicity, apoptosis, or other forms of cell death, making it a valuable tool for studying autophagic processes in various biological contexts. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
