Product Data Sheet
LT175
Catalog No. A39974
LT175 is a dual ligand targeting peroxisome proliferator-activated receptors alpha and gamma (PPARα/γ). As an orally active partial agonist, it exhibits effective receptor affinity with EC50 values of 0.22 μM for hPPARα, 0.26 μM for mPPARα, and 0.48 μM for hPPARγ. LT175 modulates coregulator recruitment, specifically cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1 (NCoR1), via interaction in the hydrophobic "diphenyl pocket" of PPARγ. This compound demonstrates significant insulin-sensitizing effects while reducing adipogenic activity, making it valuable for research in metabolic disorders.
Chemical Information
| Catalog Num | A39974 |
|---|---|
| M. Wt | 318.37 |
| Formula | C21H18O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 862901-87-9 |
| Synonyms | |
| SMILES | O=C([C@@H](OC1=CC=C(C2=CC=CC=C2)C=C1)CC3=CC=CC=C3)O |
Biological Activity
| Description | LT175 is a dual ligand targeting peroxisome proliferator-activated receptors alpha and gamma (PPARα/γ). As an orally active partial agonist, it exhibits effective receptor affinity with EC50 values of 0.22 μM for hPPARα, 0.26 μM for mPPARα, and 0.48 μM for hPPARγ. LT175 modulates coregulator recruitment, specifically cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1 (NCoR1), via interaction in the hydrophobic "diphenyl pocket" of PPARγ. This compound demonstrates significant insulin-sensitizing effects while reducing adipogenic activity, making it valuable for research in metabolic disorders. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
