Product Data Sheet
Seladelpar Lysine dihydrate
Catalog No. A40037
Seladelpar Lysine dihydrate is a potent PPAR-δ agonist with an EC50 value of 2 nM. This compound exhibits significant specificity, demonstrating over 750-fold selectivity for PPAR-δ compared to PPARα and over 2500-fold selectivity relative to PPARγ. Research applications include the investigation of primary biliary cholangitis and the modulation of metabolic conditions, including the normalization of hyperglycemia, hyperinsulinemia, serum lipids, and cholesterol levels. Additionally, Seladelpar Lysine dihydrate has been shown to ameliorate nonalcoholic steatohepatitis in mouse models.
Chemical Information
| Catalog Num | A40037 |
|---|---|
| M. Wt | 626.68 |
| Formula | C27H41F3N2O9S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 928821-40-3 |
| Synonyms | MBX-8025 Lysine dihydrate; RWJ-800025 Lysine dihydrate |
| SMILES | N[C@@H](CCCCN)C(O)=O.O=C(O)COC1=CC=C(SC[C@H](OCC)COC2=CC=C(C(F)(F)F)C=C2)C=C1C.O.O |
Biological Activity
| Description | Seladelpar Lysine dihydrate is a potent PPAR-δ agonist with an EC50 value of 2 nM. This compound exhibits significant specificity, demonstrating over 750-fold selectivity for PPAR-δ compared to PPARα and over 2500-fold selectivity relative to PPARγ. Research applications include the investigation of primary biliary cholangitis and the modulation of metabolic conditions, including the normalization of hyperglycemia, hyperinsulinemia, serum lipids, and cholesterol levels. Additionally, Seladelpar Lysine dihydrate has been shown to ameliorate nonalcoholic steatohepatitis in mouse models. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
