Product Data Sheet
MRL20
Catalog No. A40054
MRL20 is a PPARγ constitutive and allosteric agonist that enhances the interaction between PPARγ and the co-activating peptide TRAP220, exhibiting an EC50 of 10 nM. Notably, even when covalently inhibited in its constitutive pocket by GW9662 or T0070907, MRL20 can maintain its ability to facilitate the PPARγ-TRAP220 interaction, with subsequent EC50 values of 176 nM and 440 nM, respectively. This compound does not completely inhibit cell activation, making MRL20 a valuable tool for investigating the allosteric regulatory mechanisms of PPARγ in various biological contexts.
Chemical Information
| Catalog Num | A40054 |
|---|---|
| M. Wt | 527.49 |
| Formula | C28H24F3NO6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 393794-32-6 |
| Synonyms | |
| SMILES | O=C(C1=CC=C(C=C1)OC)N2C3=CC=C(OC(F)(F)F)C=C3C(CC4=C(C=CC=C4)O[C@@H](C)C(O)=O)=C2C |
Biological Activity
| Description | MRL20 is a PPARγ constitutive and allosteric agonist that enhances the interaction between PPARγ and the co-activating peptide TRAP220, exhibiting an EC50 of 10 nM. Notably, even when covalently inhibited in its constitutive pocket by GW9662 or T0070907, MRL20 can maintain its ability to facilitate the PPARγ-TRAP220 interaction, with subsequent EC50 values of 176 nM and 440 nM, respectively. This compound does not completely inhibit cell activation, making MRL20 a valuable tool for investigating the allosteric regulatory mechanisms of PPARγ in various biological contexts. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
