Product Data Sheet
GW1929 hydrochloride
Catalog No. A40081
GW1929 hydrochloride is a potent agonist of the peroxisome proliferator-activated receptor-γ (PPARγ), exhibiting a pKi of 8.84 for human PPAR-γ and pEC50 values of 8.56 for human PPAR-γ and 8.27 for murine PPAR-γ. This compound demonstrates significant antidiabetic activity and potential neuroprotective effects by suppressing neuronal apoptosis and exhibiting anti-inflammatory properties. It is a valuable tool for investigating metabolic disorders, neurodegenerative diseases, and the mechanisms of inflammation in research applications.
Chemical Information
| Catalog Num | A40081 |
|---|---|
| M. Wt | 532.03 |
| Formula | C30H30ClN3O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1217466-21-1 |
| Synonyms | |
| SMILES | O=C(C1=CC=CC=C1)C2=C(C=CC=C2)N[C@H](C(O)=O)CC3=CC=C(C=C3)OCCN(C4=CC=CC=N4)C.Cl |
Biological Activity
| Description | GW1929 hydrochloride is a potent agonist of the peroxisome proliferator-activated receptor-γ (PPARγ), exhibiting a pKi of 8.84 for human PPAR-γ and pEC50 values of 8.56 for human PPAR-γ and 8.27 for murine PPAR-γ. This compound demonstrates significant antidiabetic activity and potential neuroprotective effects by suppressing neuronal apoptosis and exhibiting anti-inflammatory properties. It is a valuable tool for investigating metabolic disorders, neurodegenerative diseases, and the mechanisms of inflammation in research applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
