Product Data Sheet
GW9662-d5
Catalog No. A40083
GW9662-d5 is a deuterium-labeled derivative of the potent PPARγ antagonist GW9662. It exhibits an IC50 of 3.3 nM for PPARγ, demonstrating significant selectivity with 10-fold affinity over PPARα and 1000-fold over PPARδ. This stable isotope variant is ideal for tracer studies and applications in metabolic research, particularly in understanding the role of PPARγ in insulin sensitivity and adipogenesis.
Chemical Information
| Catalog Num | A40083 |
|---|---|
| M. Wt | 281.71 |
| Formula | C13H4D5ClN2O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2117730-84-2 |
| Synonyms | |
| SMILES | ClC1=CC=C(C=C1C(NC2=C(C([2H])=C(C([2H])=C2[2H])[2H])[2H])=O)[N+]([O-])=O |
Biological Activity
| Description | GW9662-d5 is a deuterium-labeled derivative of the potent PPARγ antagonist GW9662. It exhibits an IC50 of 3.3 nM for PPARγ, demonstrating significant selectivity with 10-fold affinity over PPARα and 1000-fold over PPARδ. This stable isotope variant is ideal for tracer studies and applications in metabolic research, particularly in understanding the role of PPARγ in insulin sensitivity and adipogenesis. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
