Product Data Sheet
D-Arabinose-13C-3
Catalog No. A40140
D-Arabinose-13C-3 is a stable isotope-labeled form of D-Arabinose, an aldopentose sugar. It acts as a selective metabolic inhibitor, showing antidepressant properties and growth inhibition in C. elegans with an IC50 of 7.5 mM. D-Arabinose can penetrate the blood-brain barrier, influencing the metabolism of D-ribose and D-fructose, and exhibits antibacterial effects by inhibiting cell biofilm synthesis. Its mechanism involves activation of the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, which induces CRTC1 transcription and contributes to its antidepressant-like effects. This reagent is valuable for studying metabolic pathways and neuronal function in various research applications.
Chemical Information
| Catalog Num | A40140 |
|---|---|
| M. Wt | 151.12 |
| Formula | C413CH10O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 101615-87-6 |
| Synonyms | |
| SMILES | O=C[13C@H]([C@@H]([C@@H](CO)O)O)O |
Biological Activity
| Description | D-Arabinose-13C-3 is a stable isotope-labeled form of D-Arabinose, an aldopentose sugar. It acts as a selective metabolic inhibitor, showing antidepressant properties and growth inhibition in C. elegans with an IC50 of 7.5 mM. D-Arabinose can penetrate the blood-brain barrier, influencing the metabolism of D-ribose and D-fructose, and exhibits antibacterial effects by inhibiting cell biofilm synthesis. Its mechanism involves activation of the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, which induces CRTC1 transcription and contributes to its antidepressant-like effects. This reagent is valuable for studying metabolic pathways and neuronal function in various research applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
